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  • Title: [Acute cholestatic hepatitis induced by propylthiouracil. Case report].
    Author: Parolin MB, Lopes RW, Telles JE, Ioshii SO, Hajar N.
    Journal: Arq Gastroenterol; 2000; 37(2):129-32. PubMed ID: 11144016.
    Abstract:
    Propylthiouracil is widely used to treat patients with hyperthyroidism. However, propylthiouracil-induced hepatitis is an uncommon entity. The case of a 15-year-old boy treated with propylthiouracil for hyperthyroidism who developed a cholestatic acute hepatitis is reported. Viral, metabolic and autoimmune liver diseases were excluded and liver biopsy showed a pattern suggestive of drug-induced cholestatic hepatitis. After discontinuing the drug, there was a progressive resolution of symptoms and normalization of liver biochemical tests. Despite its rarity, patients receiving propylthiouracil are exposed to develop severe hepatotoxicity.
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