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  • Title: CD1 molecules and CD1-dependent T cells in bacterial infections: a link from innate to acquired immunity?
    Author: Schaible UE, Kaufmann SH.
    Journal: Semin Immunol; 2000 Dec; 12(6):527-35. PubMed ID: 11145858.
    Abstract:
    The MHC class I-like, non-polymorphic CD1 molecules represent a novel system for the presentation of glycolipid antigens to T lymphocytes. CD1-mediated T cell responses appear to play distinct roles during bacterial infections such as in tuberculosis. This review deals with two aspects of CD1-mediated immune reactions. First we discuss the role of group II CD1-dependent NK T cells in bacterial infection. Second, we provide an insight into differential intracellular meeting points for antigen processing between group I CD1 molecules, mycobacteria and mycobacterial glycolipid antigens.
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