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  • Title: [Relationship between chronic viral hepatitis and hepatocellular carcinoma].
    Author: Karev VE, Tsinzerling VA, Komarova DV, Iakovlev AA.
    Journal: Vopr Onkol; 2000; 46(4):427-32. PubMed ID: 11147418.
    Abstract:
    Recent years have seen a correlation between the rise in morbidity and lethality from chronic viral hepatitis and that of hepatocellular carcinoma. Present-day methods of hepatotropic viruses (HBV and HCV) identification point to a growing role of chronic viral hepatitis in etiology of cirrhosis which gives rise to hepatocellular cancers. A study of 49 cases based on sectional material established hepatocellular carcinoma development in smoldering chronic viral hepatitis caused by B or C virus or their combination. An immunohistochemical investigation (29) identified differences in hepatitis B and C virus antigen expression in tumor and adjacent hepatic tissue.
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