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  • Title: RNA polymerase--promoter recognition. Specific features of electrostatic potential of "early" T4 phage DNA promoters.
    Author: Kamzolova SG, Sivozhelezov VS, Sorokin AA, Dzhelyadin TR, Ivanova NN, Polozov RV.
    Journal: J Biomol Struct Dyn; 2000 Dec; 18(3):325-34. PubMed ID: 11149509.
    Abstract:
    Comparative analysis of electrostatic potential distribution for "early" T4 phage promoters was undertaken, along with calculation of topography of electrostatic potential around the native and ADP-ribosylated C-terminal domain of RNA polymerase alpha-subunit. The data obtained indicate that there is specific difference in the patterns of electrostatic potential distribution in far upstream regions of T4 promoters differing by their response to ADP-ribosylation of RNA polymerase. A specific change in profiles of electrostatic potential distribution for the native and ADP-ribosylated forms of RNA polymerase alpha-subunit was observed suggesting that this factor may be responsible for modulating T4 promoter activities in response to the enzyme modification.
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