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  • Title: Expression of Ki-67 in cervical epithelial cells in preneoplastic lesions of patients with AIDS.
    Author: Calore EE, Cavaliere MJ, Perez Calore NM, de Souza Dias S, Paes Dos Santos R, Vilela-De-Almeida L.
    Journal: Gynecol Obstet Invest; 2001; 51(1):51-4. PubMed ID: 11150876.
    Abstract:
    The objective of the present investigation was to study the expression of the proliferation marker Ki-67 in cervical intraepithelial lesions in women with AIDS. We studied 18 low-grade cervical intraepithelial lesions (Lo-CIN) and 8 high-grade cervical intraepithelial lesions (Hi-CIN ) in AIDS patients and 18 Lo-CIN and 14 Hi-CIN in patients from the general population. Positive Ki-67 nuclei were counted. A significantly higher number of Ki-67-positive cells (p < 0.001) was found in Lo-CIN of AIDS patients (mean 29.18 +/- 10.44) as compared with Lo-CIN of general-population women (mean 17.08 +/- 7.40), whereas no significant difference in positive Ki-67 nuclei was observed in the Hi-CIN of AIDS patients and of patients from the general population (p > 0.05). We conclude that the proliferative potential of cervical cells in Lo-CIN - as studied by the expression of the proliferation marker Ki-67 - is higher in AIDS patients than in the general population.
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