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  • Title: [Ocular hypotensive effect of pilocarpine in latanoprost treated eyes; a pilot study].
    Author: Teus Guezala MA, Arranz Márquez E, Morales Bertrand J, Marcos De La Huerga A.
    Journal: Arch Soc Esp Oftalmol; 2000 Nov; 75(11):735-740. PubMed ID: 11151262.
    Abstract:
    PURPOSE: To study the ocular hypotensive effect of pilocarpine in latanoprost treated eyes. METHODS: We measured the IOP in both eyes of 25 patients, before and after instillation of pilocarpine 2% in one eye, and placebo in the other. This is a prospective, double blind, placebo-controlled study. RESULTS: We found that the mean change in IOP of the study eyes was +0.4 on average (range of change from -3 to +5 mmHg), compared with the control, placebo treated eyes (p=0.5). CONCLUSIONS: The acute administration of pilocarpine in Latanoprost treated eyes seems to have a paradoxical effect on IOP, as the IOP may increase or decrease.
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