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  • Title: Levels of prostaglandins F-2alpha and E-2 in human endometrium during the menstrual cycle.
    Author: Singh EJ, Baccarini I, Zuspan FP.
    Journal: Am J Obstet Gynecol; 1975 Apr 01; 121(7):1003-6. PubMed ID: 1115176.
    Abstract:
    A comparison between the prostaglandins found in proliferative and secretory endometrium in normal and tumor-bearing tissues is reported. The content of prostaglandins F-2alpha and E-2 is related to the three phases of the menstrual cycle and correlates with cyclic ovarian hormone variations. The menstrual phase is characterized by a high content of PGF-2alpha. High prostaglandin levels are found in tissues from patients with pathologic diseases such as adenocarcinoma of the endometrium when compared to normal tissues. The levels of prostaglandin E2 (PGE2) and prostaglandin F2alpha (PGF2alpha) during a normal human menstrual cycle and in tumor-bearing endometrium were compared. Study subjects were 30 women of reproductive age who were undergoing surgery for benign gynecologic disease. Each uterus showed no pathologic or histologic disease and was the source of the normal endometrial study tissue. Another group of 12 patients with known gynecologic malignancy (adenocarcinoma of the endometrium) served as the source of tumor-bearing endometrial tissue which was taken from the extirpated uteri. The specimens were obtained from women in the early and late proliferative phases and early and late luteal phases of the menstrual cycle as well as at menstruation. The weights of the endometrium biopsy specimens were in the range of 1-3 grams. The content of PGF2alpha and PGE2 was related to the 3 phases of the menstrual cycle and correlated with cyclic ovarian hormone variations. The menstrual phase was characterized by a high content of PGF2alpha. High prostaglandin levels were found in tissues from patients with pathologic diseases such as adenocarcinoma of the endometrium when compared to normal tissues. The most significant finding was the high prostaglandin content of the endometrium at menstruation and the dominance of PGF2alpha over PGE2.
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