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  • Title: Therapeutic management of chronic venous insufficiency: microcirculation as a target.
    Author: Bergan JJ, Schmid-Schönbein GW.
    Journal: Microcirculation; 2000; 7(6 Pt 2):S23-8. PubMed ID: 11151967.
    Abstract:
    Chronic venous insufficiency, in its most severe manifestations as well as in its mild form, is linked to venous valve failure, weakness of the venous wall, and leukocyte-endothelial interactions all of which lead to cutaneous and subcutaneous tissue changes. These in turn are related to venous hypertension-induced leukocyte activation, which may provide a target for pharmacotherapeutic intervention. Currently, surgical attack is focused on correction of the sources of venous hypertension, but it is felt that this provides a crude method that hopefully wil be replaced by more precise pharmacological interventions.
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