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  • Title: Successful treatment of mediastinal gas gangrene due to esophageal perforation.
    Author: Salo JA, Savola JK, Toikkanen VJ, Perhoniemi VJ, Pettilä VY, Klossner JA, Toivonen HJ.
    Journal: Ann Thorac Surg; 2000 Dec; 70(6):2143-5. PubMed ID: 11156138.
    Abstract:
    Esophageal perforation and mediastinal gas gangrene developed in a 55-year-old male after the endoscopic ethanol injection of a Mallory-Weiss ulcer. Initially, extensive gangrene of the esophagus and the mediastinum was treated by esophagectomy; however, an abundance of Clostridium perfringens in the Gram stain verified the presence of gas gangrene. Subsequently, the patient was transferred to a hyperbaric oxygen center, wherein a total of seven hyperbaric treatments were administered. The patient survived, and 4 months later, after having undergone several reoperations because of pleural empyema, mediastinal abscess, splenic rupture, and acalculous cholecystitis, was discharged and is still surviving.
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