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  • Title: Linezolid therapy of vancomycin-resistant Enterococcus faecium experimental endocarditis.
    Author: Patel R, Rouse MS, Piper KE, Steckelberg JM.
    Journal: Antimicrob Agents Chemother; 2001 Feb; 45(2):621-3. PubMed ID: 11158767.
    Abstract:
    We compared the activities of linezolid (25 mg/kg of body weight, administered intraperitoneally every 8 h) and of vancomycin (25 mg/kg of body weight, administered intraperitoneally every 8 h) in a rat model of vanA vancomycin-resistant Enterococcus faecium experimental endocarditis. Results were expressed as median log(10) CFU per gram of vegetation after 3 days of treatment. The median log(10) CFU per gram of vegetation was 10.1 among 7 untreated control animals, 10.2 among 9 vancomycin-treated animals, and 7.9 among 10 linezolid-treated animals. Linezolid treatment was more active (P < 0.05) than vancomycin treatment or no treatment.
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