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  • Title: Retinoic acid modulates the asialoglycoprotein receptor expression in cultured fetal rat hepatocytes.
    Author: Falasca L, Felici A, Massimi M, Dini L, Conti Devirgiliis L.
    Journal: Mech Ageing Dev; 2001 Jan; 122(1):31-9. PubMed ID: 11163622.
    Abstract:
    The influence of retinoic acid on the expression of a typical marker of hepatocyte differentiation, i.e. the asialoglycoprotein receptor, has been studied. Cultured hepatocytes, isolated from adult rats, a model of quiescent, mature cells and from 20-day-old fetuses, a model of proliferating and less differentiated cells, were used. The asialoglycoprotein receptor expression appears to be affected by retinoic acid during prenatal life; both mRNA level and protein amount increased in fetal hepatocytes, but no modification has been found in adult cells, suggesting a regulative effect of retinoic acid during prenatal life, acting at transcriptional and/or translational level. Surprisingly, the receptor binding activity of adult hepatocytes is decreased after retinoic acid treatment, indicating a possible further modulation by this molecule on receptor activity at the post-translational level.
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