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  • Title: Calcineurin A and calbindin immunoreactivity in the spinal cord of G93A superoxide dismutase transgenic mice.
    Author: Knirsch U, Sturm S, Reuter A, Bachus R, Gosztonyi G, Voelkel H, Ludolph AC.
    Journal: Brain Res; 2001 Jan 19; 889(1-2):234-8. PubMed ID: 11166710.
    Abstract:
    A qualitative immunohistochemical study was performed on calcineurin A- and calbindin-positive neurons in the spinal cord of transgenic mice, an animal model of amyotrophic lateral sclerosis, carrying the G93A mutation of the Cu/Zn-superoxide dismutase gene. The results show that calcineurin A-immunoreactive motoneurons are affected by the neurodegenerative process; in contrast, calbindin-positive cells are selectively spared. The findings suggest that calcineurin plays a role as an accessory factor responsible for selective vulnerability in the neurodegenerative process of amyotrophic lateral sclerosis.
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