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  • Title: Appearance of hCG in pregnancy plasma following the initiation of implantation of the blastocyst.
    Author: Catt KJ, Dufau ML, Vaitukaitis JL.
    Journal: J Clin Endocrinol Metab; 1975 Mar; 40(3):537-40. PubMed ID: 1117063.
    Abstract:
    Plasma chorionic gonadotropin levels were measured by three different assay methods during early pregnancy in four patients following induction of ovulation with Pergonal and hCG. Radioligand-receptor assay of unextracted samples was subject to non-specific interference by plasma proteins, causing an apparent elevation of gonadotropin levels during the first few days after fertilization. By contrast, the gonadotropin values measured by a highly sensitive LH/hCG bioassay were consistent with those obtained with a sensitive and specific radioimmunoassay for hCG, and showed that the first significant rise in plasma hCG occurred 9 to 13 days after ovulation. These results indicate that hCG does not appear in the maternal circulation until after the initiation of implantation of the blastocyst. A detailed study of the changes in plasma human chorionic gonadotropin (HCG) levels during early pregnancy was performed. Plasma HCG values, as determined by radioligand-receptor assay, were compared with those of radioimmunoassay and with a sensitive bioassay capable of measuring plasma levels of luteinizing hormone and HCG. Subjects were 4 women with secondary amenorrhea of hypothalamic origin. They were treated with human menopausal gonadotropin (Pergonal) followed by 10,000 IU of HCG to induce ovulation. Blood samples were collected at the time of HCG injection and at intervals of 1-2 days thereafter. Details of techniques used are given. Plasma proteins caused a nonspecific interference 1st significant rise in plasma HCG occurs 9-12 days after ovulation. Results indicate that HCG does not appear in the maternal circulation until after the implantation of the blastocyst.
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