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  • Title: Two new stilbene dimer glucosides from grape (Vitis vinifera) cell cultures.
    Author: Waffo-Teguo P, Lee D, Cuendet M, Mérillon J, Pezzuto JM, Kinghorn AD.
    Journal: J Nat Prod; 2001 Jan; 64(1):136-8. PubMed ID: 11170689.
    Abstract:
    Two new stilbene dimer glucosides, resveratrol (E)-dehydrodimer 11-O-beta-D-glucopyranoside (1) and resveratrol (E)-dehydrodimer 11'-O-beta-D-glucopyranoside (2), were isolated together with the known resveratrol (E)-dehydrodimer (3) and pallidol (4) from Vitis vinifera cell cultures. The structures and stereochemistry of the new compounds were determined on the basis of spectroscopic data analysis. Compounds 1 and 2 are dimers that belong to a new type of oligostilbene formed from a resveratrol unit and a resveratrol glucoside unit. Compounds 1 and 3 exhibited nonspecific inhibitory activity against cyclooxygenase-1 and -2, with IC(50) values in the range of 5 microM, whereas compound 4 was approximately 10-fold less active.
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