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  • Title: Serum IgE levels during the potentiated reagin response to egg albumin in rats infected with Nippostrongylus brasiliensis.
    Author: Carson D, Metzger H, Bloch KJ.
    Journal: J Immunol; 1975 Jan; 114(1 Pt 2):521-3. PubMed ID: 1117135.
    Abstract:
    Rats were immunized with 10 mug EA and alum; a low titer IgE anti-EA response was observed; subsequent infection with N. brasiliensis greatly potentiated this response. Serum from these rats was tested for its IgE content by a recently developed radioimmunoassay for rat IgE. The average serum level of IgE was 1.15 mug/ml; this level was not altered by immunization, but infection with N. brasiliensis was accompanied by an 80-fold increase in concentration of serum IgE. This increase could not be accounted for by IgE anti-EA or anti-worm antibodies. Infection with N. brasiliensis appears to have an adjuvant effect on IgE antibody responses to diverse environmental antigens as well as the experimentally induced IgE anti-EA response.
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