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  • Title: Lactic dehydrogenase isoenzymes in human bladder cancer.
    Author: Bredin HC, Daly JJ, Prout GR.
    Journal: J Urol; 1975 Apr; 113(4):487-90. PubMed ID: 1117520.
    Abstract:
    The lactic dehydrogenase isoenzymic patterns of normal, atypical and neoplastic urothelium were studied. In comparison to normal, the atypical urothelium had a significant increase in the LDH-V/I ratio. In neoplastic urothelium the LDH-I per cent was increased in low grade tumors, while the LDH-V per cent and LDH-V/I ratio was increased in high grade tumors. The findings in high grade tumors are thought to represent altered genetic expression with activation of the gene locus controlling M subunit synthesis.
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