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  • Title: Polycythemia produced by hemoglobin Osler (beta-145 (HC2) Tyr yields Asp).
    Author: Charache S, Brimhall B, Jones RT.
    Journal: Johns Hopkins Med J; 1975 Mar; 136(3):132-6. PubMed ID: 1117598.
    Abstract:
    Polycythemia in a black woman was associated with hemoglobin Osler. In this hemoglobin the tyrosine at the penultimate position of the beta chain is replaced by aspartic acid. As a result oxygen affinity of the hemoglobin is very high, heme-heme interaction is absent, and the influence of hydrogen ion and 2,3 diphosphoglycerate on oxygen affinity is attenuated.
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