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  • Title: Age-related changes in plasma lycopene concentrations, but not in vitamin E, are associated with fat mass.
    Author: Grolier P, Boirie Y, Levadoux E, Brandolini M, Borel P, Azais-Braesco V, Beaufrère B, Ritz P.
    Journal: Br J Nutr; 2000 Nov; 84(5):711-6. PubMed ID: 11177185.
    Abstract:
    The aim of the present study was to assess the influence of age on plasma concentration of alpha-tocopherol, retinol and carotenoids with a special attention paid to natural differences in body composition. Forty healthy subjects were recruited: twenty were less than 35 years old and twenty above 60 years old. Males and females were equally represented in each age group. Subjects were kept in energy balance and received controlled diets for 36 h. Fat mass and fat-free mass were determined with the (18)0-enriched water dilution technique. Plasma vitamins A and E, and carotenoid levels were determined after 12 h fasting and were shown to be similar in women and men. Plasma alpha-tocopherol concentration increased with age (+44 % elderly v. young), and correlated with % fat mass and plasma cholesterol. After adjustment for plasma cholesterol, the effect of age and % fat mass disappeared. In contrast, plasma lycopene level was 2-fold lower in the elderly than in the young group, and was inversely correlated with fat mass. When lycopene values were adjusted for fat mass, the effect of age disappeared. These results suggest that plasma levels of vitamin E and lycopene differed in the two age groups and that differences in plasma cholesterol and fat mass might participate in such an effect. Short-term vitamin intake did not appear to influence plasma vitamin concentrations.
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