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  • Title: Modern methods for diagnosis and monitoring of nephrotoxicity during antitumor therapy with platinum derivatives.
    Author: Lyubimova NV, Topchieva SV, Averinova SG, Kashkadaeva AV, Gorbunova VA, Shiryaev SV, Kushlinskii NE.
    Journal: Bull Exp Biol Med; 2000 Sep; 130(9):886-91. PubMed ID: 11177273.
    Abstract:
    Chemotherapy is an important method of antitumor therapy. Nephrotoxicity characteristic of many cytostatics, including platinum compounds, is a serious complication limiting the drug dose [4,5,7-9]. Platinum derivatives, in particular, cisplatin, are drugs of choice in the treatment of the majority of solid tumors. However, cisplatin induces a dose-dependent toxic damage to the kidneys [5,7,8,10].
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