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  • Title: Water-soluble 99mTc-labeled dendritic novel porphyrins tumor imaging and diagnosis.
    Author: Subbarayan M, Shetty SJ, Srivastava TS, Noronha OP, Samuel AM, Mukhtar H.
    Journal: Biochem Biophys Res Commun; 2001 Feb 16; 281(1):32-6. PubMed ID: 11178956.
    Abstract:
    We have synthesized two water soluble dendritic porphyrins, termed DP1 and DP2 and have successfully radiolabeled them with 99mTc. These 99mTc-labeled porphyrins were administered to C6-glioma tumor bearing Wistar rats and scintiimaging and biodistribution studies were carried out. Tumor to muscle ratios of DP1 and DP2 were 8.0 and 9.7, respectively. These molecules may have potential for tumor imaging and diagnosis and may even prove useful as photosensitizers in photodynamic therapy applications.
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