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  • Title: Inhibition of L-dopa-induced growth hormone stimulation by pyridoxine and chlorpromazine.
    Author: Mims RB, Scott CL, Modebe O, Bethune JE.
    Journal: J Clin Endocrinol Metab; 1975 Feb; 40(2):256-9. PubMed ID: 1117978.
    Abstract:
    One gram of L-dopa was administered orally to 12 male control subjects and induced an increase of growth hormone (GH) secretion. The L-dopa-induced GH response was inhibited by an intravenous infusion of pyridoxine, but pyridoxine did not inhibit the GH response to hypoglycemia. Chlorpromazine also inhibited L-dopa-induced GH stimulation. Glucose concentrations were unaffected by L-dopa, chlorpromazine, and pyridoxine administration in these subjects. The mechanism of the suppressed L-dopa-induced GH response by pyridoxine appears to be mediated by peripheral accleration of the conversion of L-dopa to dopamine, while that of chlorpromazine appears to be mediated through hypothalamic centers. Pyridoxine and chlorpromazine should be added to the list of other factors affecting the response to L-dopa-induced GH stimulation
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