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  • Title: NdWFamide: a novel excitatory peptide involved in cardiovascular regulation of Aplysia.
    Author: Morishita F, Sasaki K, Kanemaru K, Nakanishi Y, Matsushima O, Furukawa Y.
    Journal: Peptides; 2001 Feb; 22(2):183-9. PubMed ID: 11179811.
    Abstract:
    Although diverse peptides are known to affect invertebrate cardiac activity, the peptidergic regulation of the cardiovascular system of Aplysia is still poorly understood. Asn-D-Trp-Phe-NH(2) (NdWFamide) is a recently purified cardioactive peptide in Aplysia. Pharmacological experiments showed that NdWFamide was one of the most potent cardioexcitatory peptides among the known endogenous cardioactive peptides in Aplysia. NdWFamide-immunopositive neuronal processes were abundant in the cardiovascular region of Aplysia, and many of them originated from neurosecretory cells in the abdominal ganglion (R3-R13 cells). The data suggest that NdWFamide is a cardioexcitatory peptide utilized by R3-R13 cells of Aplysia.
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