These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Separation of chiral 4-substituted imidazole derivatives by cyclodextrin-modified capillary electrophoresis.
    Author: Sasse A, Schunack W, Stark H.
    Journal: Biomed Chromatogr; 2001 Feb; 15(1):25-30. PubMed ID: 11180297.
    Abstract:
    Enantiomeric separations by cyclodextrin-modified capillary electrophoresis of chiral carbamates containing a 4-substituted imidazole heterocycle, pharmacologically acting as histamine H3-receptor antagonists, were carried out. Various cyclodextrins (alpha-, beta- and substituted beta-cyclodextrins) were investigated. Baseline resolution was achieved with six out of 11 compounds. Heptakis-2,3,6-trimethyl-beta-cyclodextrin modified buffers seemed to be most efficient in separating most of the investigated compounds. The optical purity of one pair of enantiomers was determined.
    [Abstract] [Full Text] [Related] [New Search]