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  • Title: Hypoxia promotes apoptosis of human neuroblastoma cell lines with enhanced N-myc expression.
    Author: Rössler J, Schwab M, Havers W, Schweigerer L.
    Journal: Biochem Biophys Res Commun; 2001 Feb 23; 281(2):272-6. PubMed ID: 11181040.
    Abstract:
    We have examined the effect of hypoxia and nutrient depletion on the growth of human neuroblastoma cells with normal or enhanced expression of the N-myc oncogene. The combination of both conditions reduced the growth of neuroblastoma cells with normal N-myc expression. However, this effect was much more pronounced in neuroblastoma cells with enhanced N-myc expression and eventually resulted in apoptosis, presumably by the up-regulation of CD95. Our data suggest that therapeutic induction of tumor hypoxia and nutrient depletion (for example, by anti-angiogenesis) could help to improve the outcome of patients with neuroblastomas carrying the prognostically unfavourable N-myc amplification.
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