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  • Title: [Results of a therapeutic strategy against monosymptomatic nocturnal enuresis].
    Author: Rodríguez do Forno A, Ariceta Iraola G.
    Journal: An Esp Pediatr; 2001 Jan; 54(1):38-43. PubMed ID: 11181193.
    Abstract:
    BACKGROUND: There are many therapeutic options against enuresis. OBJECTIVE: To evaluate several therapies introduced progressively to treat monosymptomatic nocturnal enuresis. METHODS: Eighty-four patients, aged 6 to 14 years old, were studied. The 67 year olds were treated with desmopressin and oxybutynin was added in nonresponders. If enuresis persisted, Alarm was given. Children over 7 years of age were randomly divided and treated with Alarm or Alarm plus desmopressin. Nonresponders were treated with desmopressin alone. RESULTS: In children aged 6-7 years the cumulative response was 72%. Those who wetted themselves less responded to desmopressin. In children over 7 years of age, response to Alarm was 73.3% and response to Alarm plus desmopressin was 58.6%. In nonresponders the cumulative response after desmopressin treatment increased to 80% and 62% respectively. CONCLUSIONS: In the group of 6 to 7 year-olds desmopressin was indicated as first line therapy. Treatment efficacy was increased by adding oxybutynin especially in the children who wetted themselves the most. In children over 7 years of age Alarm was the most effective treatment and relapses were fewer. No advantages were observed with the combination of Alarm and desmopressin in our protocol.
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