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  • Title: Activation of the alternative pathway of human complement by haemoglobin.
    Author: Wilson WA, Thomas EJ.
    Journal: Clin Exp Immunol; 1979 Apr; 36(1):140-4. PubMed ID: 111881.
    Abstract:
    Haemoglobin solutions (concentration greater than 1.5 mg/ml), prepared from lysates of erythrocytes from a normal subject and from a patient with sickle cell anaemia, caused factor B and C3 cleavage and loss of haemolytic activity of factor B wehn incubated with fresh autologous serum. Under the same experimental conditions, preparations of erythrocyte stroma or of buffycoat lysates did not produce factor B and C3 cleavage. This reaction required Mg++ but not C1q or C4, indicating that the alternative complement pathway was activated.
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