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Pubmed for Handhelds

PUBMED FOR HANDHELDS

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  • Title: DNA mismatch repair: the hands of a genome guardian.
    Author: Hopfner KP, Tainer JA.
    Journal: Structure; 2000 Dec 15; 8(12):R237-41. PubMed ID: 11188699.
    Abstract:
    DNA mismatch repair (MMR) is initiated when the MutS protein recognizes damaged DNA. Crystal structures of MutS bound to mispaired and unpaired DNA show how MutS distinguishes damaged from undamaged DNA and explain how a broad variety of DNA mismatch lesions can be detected. The structures suggest mechanisms for the ATP-induced structural regulation of multistep DNA repair processes.
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