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  • Title: [Induction of apoptosis of CD34+ cells by serum from two patients with severe aplastic anemia].
    Author: Liu H, Wu F, Jiang S.
    Journal: Zhonghua Xue Ye Xue Za Zhi; 1998 Oct; 19(10):514-7. PubMed ID: 11189494.
    Abstract:
    OBJECTIVE: To explore the relationship between the hematopoietic inhibitor and apoptosis of CD34+ cells in patients with severe aplastic anemia (SAA). METHODS: The inhibiting activity to the growth of both BFU-E and CFU-GM was analysed by in vitro methylcellulose culture and CD34+ cell apoptosis was assayed with a kit of programmed cell death assay and flow cytometry. RESULTS: Sera from two SAA patients suppressed the growth of normal hematopoietic progenitor cells and induced CD34+ cell apoptosis. Serum immunoglobulin fraction assay showed that the inhibiting activity was in the IgG fraction which bound specifically to CD34+ cells. CONCLUSION: There was an inhibitive IgG fraction, which induced CD34+ cell apoptosis, in the serum of SAA patients and CD34+ cell apoptosis might be a part of the pathogenesis of SAA.
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