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  • Title: [In vitro study on arsenic trioxide-induced apoptosis of retinoic acid resistant acute promyelocytic leukemia cell line(MR-2)].
    Author: Cai X, Jia P, Shi X.
    Journal: Zhonghua Xue Ye Xue Za Zhi; 1998 Jul; 19(7):339-41. PubMed ID: 11189513.
    Abstract:
    OBJECTIVE: To study the possible mechanisms of arsenic trioxide (As2O3) in the treatment of acute promyelocytic leukemia (APL). METHODS: Retinoic acid resistant APL cell line MR-2 was used as in vitro model. The effect of As2O3 on MR-2 cell line was observed by cell viability, cell growth, cell morphology, flow cytometry assay, NBT reduction test and immunofluorescence analysis. RESULTS: 1.0 mumol/L of As2O3 could induce apoptosis of MR-2 cells and it correlated with the degradation of PML-RAR alpha fusion protein. CONCLUSIONS: The therapeutic effect of As2O3 for APL possibly differs from that of ATRA, however, PML-RAR alpha fusion protein may be the target of both the therapy.
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