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  • Title: Characterization of an unusual variant mRNA of human lysosomal alpha-mannosidase.
    Author: Sun H, Wolfe JH.
    Journal: Exp Mol Med; 2000 Dec 31; 32(4):187-92. PubMed ID: 11190268.
    Abstract:
    Lysosomal alpha-mannosidase (EC 3.2.1.24) is an exoglycosidase in the glycoprotein degradation pathway and is encoded by a 3.0 kb cDNA. A 2.3 kb cDNA from a minor species of HeLa cell mRNA was discovered by RT-PCR cloning. Southern blotting and PCR analysis of the HeLa cell genomic DNA showed that the 2.3 kb message was encoded by the lysosomal alpha-mannosidase gene. Sequence comparison of the cDNA with the corresponding genomic DNA indicated that the 2.3 kb message was generated by an unusual intra-exonic joining event.
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