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  • Title: Cell renewal of gastric mucosa in Zollinger-Ellison syndrome.
    Author: Castrup HJ, Fuchs K, Peiper HJ.
    Journal: Acta Hepatogastroenterol (Stuttg); 1975 Feb; 22(1):40-3. PubMed ID: 1119303.
    Abstract:
    In Zollinger-Ellison patients the gastric mucosa is characterized histologically by hyperplasia both of the glands and the gastric pits. The fundic gastric mucosa is thickened with a marked increase of the specific glandular cells. In-vitro autoradiographic examination shows a significant increase in proliferation of the stomach epithelial cells in three patients with hypergastrinaemia. The mean generation time was diminished from 72 plus or minus 2 in controls to 45 plus or minus 4 hours in the Zollinger-Ellison patients owing to a reduction of the G-1 phase from 62-63 to 36-37 hours. The labelling index (3-H-index) was increased from 10.0 plus or minus 0.2 to 15.7 plus or minus 1.8%. The DNA synthesis phase, the G-2 phase, and the mitotic time were not altered compared to the controls.
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