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  • Title: Depressed cell-mediated immunity in megaloblastic anemia due to folic acid deficiency.
    Author: Gross RL, Reid JV, Newberne PM, Burgess B, Marston R, Hift W.
    Journal: Am J Clin Nutr; 1975 Mar; 28(3):225-32. PubMed ID: 1119420.
    Abstract:
    Cell-mediated immunity has been studied in patients with 1) megaloblastic anemia of folic acid deficiency, 2)megaloblastic anemia of pregnancy, or 3) iron-deficiency anemia. Using dinitrochlorobenzene skin tests, phytohemagglutinin-stimulated lymphocyte transformation, and rosette inhibition by antilymphocyte globulin, we have shown that cell-mediated immunity is depressed in megaloblastic anemia due to folate deficiency; this depression was reversed by folate treatment. Cell-mediated immunity was not impaired by iron-deficiency anemia. Suggested interactions between iron deficiency and folate metabolism were not clarified by these studies.
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