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  • Title: Genetic screening for progressive retinal atrophy in the Australian population of Irish Setters.
    Author: Maroudas P, Jobling AI, Augusteyn RC.
    Journal: Aust Vet J; 2000 Nov; 78(11):773-4. PubMed ID: 11194724.
    Abstract:
    OBJECTIVE: To determine whether the rcd-1 mutation causing progressive retinal atrophy (PRA) in Irish Setters is in the Australian breeding population. METHOD: DNA samples were tested for the mutation using the Polymerase Chain Reaction and specific primer nucleotides to amplify the phosphodiesterase gene followed by restriction enzyme cleavage and fragment size determination. RESULTS: No mutant alleles were found in 38 Irish Setters, representing over 80% of all major breeding stock in five Australian states. CONCLUSIONS: It is likely that the Australian population of Irish Setters is free of the rcd-1 form of PRA.
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