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  • Title: A highly polymorphic CA repeat marker at the interleukin-11 locus.
    Author: Ota N, Nakajima T, Takeuchi T, Shirai Y, Emi M.
    Journal: Genes Immun; 1999 Nov; 1(2):159-60. PubMed ID: 11196664.
    Abstract:
    The interleukin-11 (IL-11) stimulates T cell-dependent development of immunoglobulin-producing B cells and collaborates with IL-3 in supporting murine megakaryocyte colony formation. The interleukin-11 (IL-11) also stimulates osteoclast formation and inhibits osteoclast function in vitro and has been implicated in estrogen deficiency-induced bone loss. We isolated a polymorphic dinucleotide (CA) repeat sequence from a genomic clone containing the IL-11 gene located at 19q13.3-q13.4. High heterozygosity (0.81) makes this polymorphism a useful marker in genetic study of disorders affecting immune response and bone metabolism.
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