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  • Title: VEGF is causative for pulmonary hypertension in a patient with Crow-Fukase (POEMS) syndrome.
    Author: Niimi H, Arimura K, Jonosono M, Hashiguchi T, Kawabata M, Osame M, Kitajima I.
    Journal: Intern Med; 2000 Dec; 39(12):1101-4. PubMed ID: 11197800.
    Abstract:
    We report a case of Crow-Fukase (POEMS) syndrome associated with pulmonary hypertension (PH). In this case, the concentration of vascular endothelial growth factor (VEGF) was extremely high in the serum, and the levels of IL-1beta, IL-6, TNF-alpha, and thiamine, which were thought in past reports to be mediators of PH in Crow-Fukase syndrome, were normal. After prednisolone therapy, PH disappeared with a dramatic decrease in serum VEGF. Our results suggest that VEGF is closely correlated with PH in Crow-Fukase syndrome.
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