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  • Title: [Effect of N-acylethanolamines on adrenal cortex function].
    Author: Hula NM, Mikosha OS, Zhukov OD, Chelnakova IS.
    Journal: Ukr Biokhim Zh (1999); 2000; 72(3):82-6. PubMed ID: 11200481.
    Abstract:
    The possibility of NAE to take part in the regulation of the function of adrenal glands was studied. It was shown that two times NAE (18:0) injection in a dose 5 mg/kg of weight increased the content of 11-hydroxysteroids in blood of intact male rats. NAE caused the raise of the blood hormone content by 4 times under the immobilization stress. It is apparent that augment of stress response under the influence of NAE in vivo is explained by the activation of hypophysis-adrenal cortex system. In vitro NAE lowered steroidogenesis by near 40%. One can suggest that this decrease is caused by membranotropic properties of NAE.
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