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  • Title: Megaloblastic anemia due to folic acid deficiency after oral contraceptives.
    Author: Barone C, Bartoloni C, Ghirlanda G, Gentiloni N.
    Journal: Haematologica; 1979 Apr; 64(2):190-5. PubMed ID: 112009.
    Abstract:
    A young patient was hospitalized for megaloblastic anemia due to folate deficiency. Laboratory exams and functional tests demonstrated that the deficiency was due to hormonal contraception treatment on which the woman had been for the last consecutive 11 months. The disease subsided completely following withdrawal of oral contraception (OC), and normal hematological values were maintained after that, suggesting that no malabsorption was present. Cases of megaloblastic anemia in women on OC are rare, and the phenomenon may be related to prolonged and uninterrupted drug assumption.
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