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  • Title: Inhibitory effects of ethaverine, a homologue of papaverine, on dopamine content in PC12 cells.
    Author: Shin JS, Lee JJ, Kim Y, Lee CK, Yun YP, Lee MK.
    Journal: Biol Pharm Bull; 2001 Jan; 24(1):103-5. PubMed ID: 11201237.
    Abstract:
    The inhibitory effects of ethaverine on dopamine content in PC12 cells were investigated. Ethaverine decreased dopamine content in a concentration-dependent manner in PC12 cells and showed 33.6% inhibition of dopamine content at a concentration of 1.0 microM for 24-48 h. The IC50 value of ethaverine was 1.4 microM. Dopamine content was lowered at 6h and reached a minimal level at 12h after exposure to ethaverine at 2.0 microM. The decreased dopamine level was maintained up to 48 h and then recovered to the control level at about 72 h. Tyrosine hydroxylase (TH) was inhibited at 6 h following treatment with ethaverine in PC12 cells and the activity was maintained at a reduced level up to 36 h (12-22% inhibition at 2.0 microM). These results indicate that ethaverine leads to a decrease in dopamine content by inhibition of TH activity.
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