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  • Title: Delayed hypersensitivity to 5-fluorouracil following topical chemotherapy of cutaneous cancers.
    Author: Mansell PW, Litwin MS, Ichinose H, Krementz ET.
    Journal: Cancer Res; 1975 May; 35(5):1288-94. PubMed ID: 1120313.
    Abstract:
    Skin tests to various common antigens, dinitrochlorobenzene, and 5-fluorouracil (5-FU) were performed on patients being treated for cutaneous neoplasms with topical 5-FU cream. Eleven of 15 patients tested both before and after therapy converted from skin test negative to positive with respect to 5-FU. This conversion correlated with positive dinitrochlorobenzene skin tests and therapeutic cure. The relation between the induction of delayed hypersensitivity reactions to 5-FU following treatment with topical 5-FU and the cure rate for cutaneous neoplasms showed a trend toward correlation.
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