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  • Title: Catechol estrogen formation in the central nervous system of the rat.
    Author: Fishman J, Norton B.
    Journal: Endocrinology; 1975 Apr; 96(4):1054-8. PubMed ID: 1120471.
    Abstract:
    Conversion of estradiol and estrone to catechol estrogens by rat hypothalamic tissue but not by the cerebral cortex was demonstrated from the incubation of these tissues with estradiol-2-3H and estrone-2-3H and monitoring the incorporation of tritium into water. Direct evidence for this transformation was obtained by isolating the labelled phenazine derivative of 2-hydroxyestrone after hypothalamic incubation with estrone-4-14C.
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