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  • Title: Prolonged coma and loss of brainstem reflexes following amitriptyline overdose.
    Author: Roberge RJ, Krenzelok EP.
    Journal: Vet Hum Toxicol; 2001 Feb; 43(1):42-4. PubMed ID: 11205078.
    Abstract:
    Severe tricyclic antidepressant (TCA) overdose is generally manifested by cardiovascular and/or central nervous system toxicity. Although the majority of patients who are comatose following these overdoses regain consciousness within 24 h, this case had 5-days of coma with associated loss of brainstem reflexes. Severe central nervous system depression can occur as a sole manifestation of TCA overdose without concomitant cardiovascular toxicity.
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