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  • Title: Cyanide-induced free radical production and lipid peroxidation in rat brain homogenate is reduced by aspirin.
    Author: Daya S, Walker RB, Anoopkumar-Dukie S.
    Journal: Metab Brain Dis; 2000 Sep; 15(3):203-10. PubMed ID: 11206589.
    Abstract:
    The neuroprotective properties of aspirin were investigated using cyanide-induced neurotoxicity as model. Cyanide, a known neurotoxic agent significantly increased lipid peroxidation and superoxide anion levels in rat brain homogenate in a concentration-dependent manner (0.25-1.0 mM). When homogenate, containing 1.0 mM KCN was co-treated with aspirin (1.0 mM) there was a significant decrease in lipid peroxidation. Aspirin (0.5 mM and 1.0 mM) also significantly reduced KCN-induced superoxide anion generation. The results of the present report therefore indicate a neuroprotective role for aspirin.
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