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  • Title: Cycloalkanones. 6. Separation of hypocholesterolemic and antifertility activities in derivatives of 2,8-dibenzylcyclooctanone.
    Author: Carlson GL, Hall IH, Piantadosi C.
    Journal: J Med Chem; 1975 Apr; 18(4):432-4. PubMed ID: 1121011.
    Abstract:
    Fluoro and hydroxy derivatives of 2,8-dibenzylcyclooctanone were prepared. Separation of antifertility activity from hypolipidemic and uterotropic effects was achieved with 2,8-bis(4-acetoxybenzyl)cyclooctanone. Some enhancement of the hypolipidemic effect in relation to the uterotropic and antifertility activities was seen in 2,8-bis(4-fluorobenzyl)cyclooctanone. Synthetic methods for the hydroxy compounds are presented.
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