These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: [Cytotoxic and cytostatic effect of avermectines on tumor cells in vitro].
    Author: Mosin VA, Krugliak EB, Sterlina TS, Korystov IuN, Shaposhnikova VV, Narimanov AA, Kublik LN, Levitman MKh, Viktorov AV, Driniaev VA.
    Journal: Antibiot Khimioter; 2000; 45(10):10-4. PubMed ID: 11212393.
    Abstract:
    Effect of natural avermectin complex (aversectin C) and separate avermectins A1, A2, B1 and B2 in the cell culture of murine myeloma Ns/o, Erlich carcinoma ascites and human larynx carcinoma Hep-2 was investigated. It was shown that aversectin C within the concentrations of 0.1 to 1.0 mcg/ml inhibited proliferation of tumor cells and induced their death. Proliferation inhibition was due to the delay of the cells cycle start (lag-phase prolongation) and blocking of mitotic cycle. Ns/o cells death had apoptosis signs: chromatin condensation and fragmentation, DNA fragmentation. It was demonstrated that only avermectin A1 has cytotoxic activity within the concentrations used, avermectins A2 and B2 had cytostatic activity, avermectin B1 showed no activity under the experimental conditions.
    [Abstract] [Full Text] [Related] [New Search]