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  • Title: Labelling of Re-ABP with 188Re for bone pain palliation.
    Author: Arteaga de Murphy C, Ferro-Flores G, Pedraza-López M, Meléndez-Alafort L, Croft BY, Ramírez FM, Padilla J.
    Journal: Appl Radiat Isot; 2001 Mar; 54(3):435-42. PubMed ID: 11214878.
    Abstract:
    Etidronate and medronate have been labelled with technetium-99m (99mTc-HEDP, 99mTc-MDP) for bone scanning and, with rhenium-188 (188Re-HEDP) to palliate the pain resulting from bone metastases. The objective of this study was to label alendronate, ABP, a new bisphosphonate, with SnF2-reduced-188Re. The reagents for the 5 mg ABP kit were SnF2, KReO4 and gentisic acid at acid pH. The chemical, spectroscopic and microscopic characteristics, quality control, rat bone uptake of [188Re]Re-ABP and similarities with 99mTc-ABP are presented. We conclude that this is a promising new radiopharmaceutical for bone metastases pain palliation.
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