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  • Title: Temperature dependence of the topology of supported dimirystoyl-distearoyl phosphatidylcholine bilayers.
    Author: Giocondi MC, Pacheco L, Milhiet PE, Le Grimellec C.
    Journal: Ultramicroscopy; 2001 Jan; 86(1-2):151-7. PubMed ID: 11215618.
    Abstract:
    Topology of fluid and gel domains in the supported bilayer two-component system formed from equimolar mixtures of dimyristoylphosphatidylcholine (DMPC) and distearoylphosphatidylcholine (DSPC) was determined by AFM, at various temperatures corresponding to the gel and the gel + fluid region of the phase diagram. The data show that, in the disconnected fluid part of the DMPC/DSPC gel-liquid crystal-phase-separation region, the size of fluid domains markedly exceeds that predicted from spectroscopic experiments or from Monte Carlo simulations. They provide a direct evidence for the transition from the disconnected fluid to the disconnected gel region of the phase diagram, again with gel-phase domains much larger than expected. Finally, images of the gel phase at different temperatures suggest that structural rearrangements of the phospholipids can disrupt the continuity of the supported bilayer.
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