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  • Title: A low dose of ionizing radiation increases luminal release of intestinal peptidases in rats.
    Author: Fittkau M, Grothey A, Gerlach R, Schmoll HJ.
    Journal: J Cancer Res Clin Oncol; 2001 Feb; 127(2):96-100. PubMed ID: 11216920.
    Abstract:
    PURPOSE: Mucosal inflammation in the small intestine is a potentially hazardous side effect of abdominal irradiation. In an effort to develop a quantitative method of evaluating mucosal damage, the luminal release of brush border enzymes in response to ionizing radiation was examined using two investigational strategies. METHODS: First, a 20 cm segment of the proximal jejunum was perfused in situ and enzymatic activities within the perfusates were evaluated. In a second approach, enzymatic activities were directly evaluated in isolated brush border membranes from the jejunal mucosa. RESULTS: Most of the peptidase activities measured were increased in the perfusates 1 day after irradiation and had returned to control levels at 4 days. In the brush border membranes, some enzyme activities decreased at 1 day and were, with the exception of leucineaminopeptidase (LAP), similar to control levels at 4 days. CONCLUSIONS: LAP is more strongly affected by radiation than the transmembranously bounded enzymes.
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