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  • Title: Pro-Frame: similarity-based gene recognition in eukaryotic DNA sequences with errors.
    Author: Mironov AA, Novichkov PS, Gelfand MS.
    Journal: Bioinformatics; 2001 Jan; 17(1):13-5. PubMed ID: 11222258.
    Abstract:
    Performance of existing algorithms for similarity-based gene recognition in eukaryotes drops when the genomic DNA has been sequenced with errors. A modification of the spliced alignment algorithm allows for gene recognition in sequences with errors, in particular frameshifts. It tolerates up to 5% of sequencing errors without considerable drop of prediction reliability when a sufficiently close homologous protein is available (normalized evolutionary distance similarity score 50% or higher).
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