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  • Title: Discriminative stimulus effects of H(1)-anti-histamines in cocaine-trained pigeons.
    Author: Zacny JP.
    Journal: Behav Pharmacol; 1989; 1(3):261-265. PubMed ID: 11224038.
    Abstract:
    Pigeons (n = 4) were trained to discriminate cocaine (3.0mg/kg, i.m.) from saline in a two-key, food-reinforced drug discrimination paradigm. After acquisition of the discrimination, the H(1)-antihistamines, chlorpheniramine, tripelennamine, diphenhydramine, promethazine and hydroxyzine, were administered before test sessions to determine if these antihistamines shared discriminative stimulus (DS) effects with cocaine. Chlorpheniramine (0.3-5.6mg/kg) and tripelennamine (0.1-1.7mg/kg) substituted, (i.e. > 80% cocaine-key responding) in all four birds. Diphenhydramine (0.1-10mg/kg) and promethazine (0.1-56mg/kg) substituted for cocaine in three and two birds, respectively, while hydroxyzine (1.0-100mg/kg) did not substitute for the training drug in any bird. These results, in conjunction with results from a previous study in which several antihistamines shared DS effects with d-amphetamine, suggest that the DS effects of some H(1)-antihistamines may be similar to those of psychomotor stimulants.
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