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  • Title: Hypertonic saline mimics the effects of vasopressin and social recognition in rats.
    Author: Bluthé RM, Koob GF, Dantzer R.
    Journal: Behav Pharmacol; 1991 Dec; 2(6):513-516. PubMed ID: 11224093.
    Abstract:
    Injection of hypertonic saline to adult male rats following exposure to a juvenile, at a dose known to release peripheral and central vasopressin (10ml/kg i.p. of an 0.5M solution), decreased social exploration of the same juvenile when it was presented 2h later. This effect of hypertonic saline was blocked by pretreatment with subcutaneous injection of 30mg/kg dPTyr (Me) AVP, an antagonist of the vasopressor receptors of vasopressin, in intact but not in castrated male rats. These results are interpreted in terms of the involvement of androgen-dependent vasopressinergic neurotransmission in social recognition.
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